We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
Read More
8
Folic acid boosts cognitive function
Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies.
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
Read More
Most Useful Reviews
9
Significant improvement
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
Read More
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Read More
9
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
Read More
8
Folinic acid may aid CFS
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
Read More
8
Folic acid boosts cognitive function
Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies.
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
Read More
2
No significant benefit from folate
Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
We conducted a carefully designed study to investigate the effects of an injectable treatment combining bovine liver extract, folic acid, and cyanocobalamin on chronic fatigue syndrome (CFS). This involved a double-blind, placebo-controlled crossover trial with 15 patients who met definitive criteria for CFS.
Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.
This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Significant improvement
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
Read More
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
Read More
9
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.
Read More
9
Improved sleep quality
21 people found this helpful
After giving birth, I experienced persistent fatigue and pain in my legs, particularly at night, making sleep difficult. I decided to take iron tests, which showed I had low levels. Since starting this medication, my leg pain has lessened and my sleep has improved significantly. I still feel a slight deficiency, so I will continue seeking a solution.
Read More
7.5
Boosted energy levels
17 people found this helpful
Initially, I took one tiny capsule daily, but after discovering my MTHFR issue, I tried taking ten over two days. The effect was astonishing; I felt energetic for five days and woke easily each morning, even after heavy drinking. My usual need for 12 hours of sleep decreased to just 9. I plan to increase my dosage.
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Folic acid, also known as vitamin B9, is a water-soluble vitamin that plays a crucial role in many bodily functions, particularly in the synthesis of DNA and RNA. It is essential for cell division and is especially important during periods of rapid growth, such as during pregnancy and infancy. The body cannot produce folic acid on its own, which is why it must be obtained from dietary sources or supplements. Commonly found in leafy green vegetables, legumes, seeds, and fortified foods, folic acid is vital for preventing neural tube defects in developing fetuses and is often recommended for women of childbearing age.
In addition to its key role in pregnancy, folic acid contributes to the production of red blood cells and can help reduce the risk of certain types of anemia. Research has also suggested that adequate folic acid levels may be associated with lowered risk of heart disease and other health issues. Most health organizations recommend a daily intake of 400 micrograms for adults, with higher amounts suggested for pregnant women. Incorporating folate-rich foods into your diet, or considering supplementation, can help ensure you meet your folic acid needs.
Based on user reviews, many individuals taking this supplement for Chronic Fatigue Syndrome report experiencing noticeable improvements within a month of consistent use. For example, one reviewer noted, "Within a month, I felt noticeably different, with enhanced strength and energy" Read Review. Another user stated that after starting their regimen, they "felt revitalized with more energy and mental clarity" Read Review.
Additionally, users emphasized the importance of gradually increasing the dosage to maximize benefits, which suggests that individual responses may vary based on initial health status and the specific dosage regimen followed. In summary, while some may see results in as little as a month, others may require a longer adjustment period or a tailored dosage to achieve optimal relief from chronic fatigue symptoms.
Research indicates that certain forms of folate, including folic acid and folinic acid, may have beneficial effects for individuals suffering from Chronic Fatigue Syndrome (CFS). A study revealed that 81% of patients treated with folinic acid experienced notable symptom improvements, suggesting a potential therapeutic role for this compound, particularly for those with immune deficiencies related to Epstein-Barr virus (EBV) [2]. Additionally, another investigation found that patients receiving folic acid alongside vitamin B12 showed significant relief in symptoms, particularly when higher doses were administered [1]. This dual supplementation potentially addresses underlying deficiencies that can exacerbate fatigue symptoms.
While these findings are promising, it is essential to note that not all studies unanimously support the efficacy of folate in treating CFS. For instance, one study indicated that while many patients exhibited low serum folate levels, it didn’t establish a direct cause-and-effect relationship with symptom improvement, highlighting the need for further exploration in this area [4]. Overall, while there is some scientific support for folate-based supplements, the need for continued research and patient-specific treatment strategies remains clear.
Based on user reviews, many individuals have reported significant improvements in symptoms related to chronic fatigue syndrome after taking this supplement. Users noted enhanced energy levels and mental clarity, with one reviewer stating, "Methylfolate transformed my life" as they experienced a marked improvement in mood and energy after starting the supplement Read Review. Others have shared similar experiences, describing noticeable differences in their strength and vitality within a month of use, particularly emphasizing the supplement's role in improving iron absorption and alleviating fatigue Read Review.
Additionally, some users highlighted the importance of adjusting dosages to optimize benefits, stating that while they felt revitalized and saw a marked decrease in fatigue, individual experiences can vary based on health status and specific intake regimens Read Review. The supplement has also been noted to improve symptoms of associated conditions, such as restless leg syndrome Read Review. Overall, while anecdotal evidence suggests many users find relief with this supplement, individual results may differ.
Based on user reviews, many individuals combining this supplement with other vitamins, such as B12, report enhanced overall effectiveness in managing Chronic Fatigue Syndrome (CFS). One user noted, “I can’t identify any specific difference with this supplement, which is fine as it helps me maintain my normal state and manage chronic fatigue syndrome more effectively, especially when taken with B12” Read Review. Similarly, another reviewer claimed to combine it with active vitamin B6, stating that this combination effectively combats fatigue and improves symptoms of CFS Read Review.
In addition, users mentioned adjusting their dosages to optimize the benefits of this supplement alongside others. For instance, one user highlighted their positive experience increased energy levels after taking multiple doses over a short period, suggesting that such adjustments can lead to remarkable improvements in vitality Read Review. Overall, these reviews suggest that pairing this supplement with other supportive vitamins may significantly enhance its impact on chronic fatigue symptoms.
Based on user reviews, the right dose of Folic Acid (often mentioned in its more active form, methylfolate) for treating Chronic Fatigue Syndrome (CFS) varies amongst individuals, with many reporting a need to adjust their dosage for optimal results. For example, one user noted that they initially took one capsule daily but found substantial improvement after increasing their intake dramatically to ten capsules over two days, which led to an impressive boost in energy and mood Read Review. Others indicated that a daily capsule sufficed in alleviating symptoms, especially when paired with B12 Read Review.
Multiple users highlighted the importance of individual adjustments based on personal health conditions, like MTHFR mutations, which can affect folic acid absorption and efficacy Read Review. While some found relief with a standard dose, others experienced improved outcomes with higher intake levels, suggesting that those with CFS may benefit from experimenting with their dosage under guidance from a healthcare provider to discover what works best for them.
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
9
Significant improvement
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
9
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.
7.5
Boosted energy levels
17 people found this helpful
Initially, I took one tiny capsule daily, but after discovering my MTHFR issue, I tried taking ten over two days. The effect was astonishing; I felt energetic for five days and woke easily each morning, even after heavy drinking. My usual need for 12 hours of sleep decreased to just 9. I plan to increase my dosage.
9
Improved leg condition
1 people found this helpful
I take folate rather than folic acid, even outside of pregnancy, and have found it beneficial for my health. Despite not having taken it prior to my first pregnancy, I believe it could help avoid passing hereditary health issues onto my child. It has alleviated my restless leg syndrome symptoms, which caused significant discomfort at night.
7.5
Helps maintain normalcy
I can't identify any specific difference with this supplement, which is fine as it helps me maintain my normal state and manage chronic fatigue syndrome more effectively, especially when taken with B12.
7
High absorption rate
I combine this active vitamin B supplement for vitamins 6, 9, and 12 due to its impressive absorption, which helps combat fatigue and chronic fatigue syndrome effectively.
8
Folinic acid may aid CFS
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
8
Folic acid and B12 show variable benefits
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.
While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.
This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
References
Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.
Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230.
Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645.
Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501.