Last update
5/6/2025
Research Authors

Overview

SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Good
Based on 19 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%

Top Medical Research Studies

8
Folinic acid may aid CFS
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
8
Folic acid boosts cognitive function
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.

In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.

After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.

While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.

This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.

Most Useful Reviews

9
Significant improvement
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
9
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
  • All Researches
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.

Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.

Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
8
Folinic acid may aid CFS
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
8
Folic acid boosts cognitive function
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.

In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.

After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.

While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.

This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.
2
No significant benefit from folate
We conducted a carefully designed study to investigate the effects of an injectable treatment combining bovine liver extract, folic acid, and cyanocobalamin on chronic fatigue syndrome (CFS). This involved a double-blind, placebo-controlled crossover trial with 15 patients who met definitive criteria for CFS.

Throughout the study, patients received both the treatment and a placebo in alternating phases. While we observed that both the treatment and placebo seemed to provide some improvement in functional status for the patients, our analysis showed no significant advantage of the liver extract and folic acid combination over the placebo.

This indicates that the response to folate, particularly, is unclear as the placebo effect appeared to be notably strong among participants. Overall, the findings suggest that further research may be needed to ascertain the definitive role of folate in managing chronic fatigue syndrome.

User Reviews

USERS' SCORE
Good
Based on 19 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Significant improvement
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
9
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.
9
Improved sleep quality
21 people found this helpful
After giving birth, I experienced persistent fatigue and pain in my legs, particularly at night, making sleep difficult. I decided to take iron tests, which showed I had low levels. Since starting this medication, my leg pain has lessened and my sleep has improved significantly. I still feel a slight deficiency, so I will continue seeking a solution.
7.5
Boosted energy levels
17 people found this helpful
Initially, I took one tiny capsule daily, but after discovering my MTHFR issue, I tried taking ten over two days. The effect was astonishing; I felt energetic for five days and woke easily each morning, even after heavy drinking. My usual need for 12 hours of sleep decreased to just 9. I plan to increase my dosage.

Frequently Asked Questions

9
Increased energy levels
2 people found this helpful
I initially purchased iron and B12 separately to raise my ferritin levels. Within a month, I felt noticeably different, with enhanced strength and energy after years of chronic fatigue syndrome. This supplement greatly improved my iron absorption, a process that had proven ineffective before.
9
Significant improvement
14 people found this helpful
I have been using this supplement for a couple of years after discovering I have the MTHFR gene mutation, which necessitates its use. Upon starting, I felt revitalised with more energy and mental clarity. I had to gradually increase the dosage due to chronic fatigue syndrome, but I’ve seen significant improvement and will continue using it.
9
Life-changing effects
Methylfolate transformed my life. I struggled with depression and fatigue, but after taking it, I experienced a marked improvement in my mood and energy levels, which helped with my chronic fatigue syndrome.
7.5
Boosted energy levels
17 people found this helpful
Initially, I took one tiny capsule daily, but after discovering my MTHFR issue, I tried taking ten over two days. The effect was astonishing; I felt energetic for five days and woke easily each morning, even after heavy drinking. My usual need for 12 hours of sleep decreased to just 9. I plan to increase my dosage.
9
Improved leg condition
1 people found this helpful
I take folate rather than folic acid, even outside of pregnancy, and have found it beneficial for my health. Despite not having taken it prior to my first pregnancy, I believe it could help avoid passing hereditary health issues onto my child. It has alleviated my restless leg syndrome symptoms, which caused significant discomfort at night.
7.5
Helps maintain normalcy
I can't identify any specific difference with this supplement, which is fine as it helps me maintain my normal state and manage chronic fatigue syndrome more effectively, especially when taken with B12.
7
High absorption rate
I combine this active vitamin B supplement for vitamins 6, 9, and 12 due to its impressive absorption, which helps combat fatigue and chronic fatigue syndrome effectively.
8
Folinic acid may aid CFS
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.

Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.

Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
We investigated the connection between serum folate levels and chronic fatigue syndrome (CFS) in a group of 60 patients. Our findings revealed that a striking 50% of these individuals had folate levels below 3.0 micrograms per liter, indicating a potential deficiency in this essential nutrient.

While it’s clear that some patients with CFS are not getting enough folic acid, our study stops short of establishing a direct cause-and-effect relationship. The information lacks treatment outcome data, which means we cannot definitively say that folate supplementation will improve symptoms of CFS or enhance overall well-being.

This research sheds light on a potential factor affecting those with chronic fatigue syndrome and underlines the importance of monitoring vitamin levels in patients. However, further studies are essential to determine the role folate supplementation might play in managing this complex condition.

References

  1. Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
  2. Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.
  3. Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230.
  4. Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645.
  5. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501.
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